The scales for benzodiazepine and narcotic withdrawal detection used in paediatrics population correlate well with the DSM V diagnosis of withdrawal in an adult ICU population 3. Symptoms of iatrogenic benzodiazepines and opioids withdrawal occur commonly in mechanically ventilated patients exposed to high doses and/or prolonged infusions and who are rapidly weaned from these therapies. The objectives of the study are: 1) to describe the incidence of iatrogenic withdrawal of sedatives and analgesics in critically ill adult patients and 2) Validate screening tools for withdrawal in the adult population. Methods: Prospective observational two-center study in critically ill adult patients Objectives: 1) Describe the incidence of iatrogenic withdrawal of sedatives and analgesics in critically ill adult patients and 2) Evaluate the performance of screening tools assessing withdrawal that were developed for the paediatric patient in the adult population. Studying this problem is essential as we strive to develop proper weaning strategies. Although well studied in the paediatric population, little is known about the epidemiology, risk factors and optimal screening methods in adults. These withdrawal symptoms may be associated with adverse clinical outcomes. Their prolonged use has been associated with withdrawal symptoms upon rapid weaning in critically ill patients. Opioids Withdrawal Syndrome in Critically Ill Patients: a Multicenter Prospective Cohort StudyД¬ritically ill patients who are mechanically ventilated may require prolonged administration of sedatives and analgesics.

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